How to Change the Dressing of Your Peripherally Inserted Central Catheter (PICC) Every 7 days we change my PICC line dressings to keep my line clean and safe. Last night we changed it again at home with speciality supplies. Ps: medical glue into an open wound flipping HURTS!! But How Often Do You Change A Picc Line Dressing PICC CVC Securement Device + Tegaderm I.V. Advanced Securement Dressing 5 Common Questions on PICC Line Dressing Changes Answered Mighty Well Journal PICC Line and Midline Catheter Care Vascular Wellness